Anti-Allergic Effects of Fermented Red Ginseng Marc on 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-like Mice Model

Atopic dermatitis (AD) is a chronic and allergic skin disease; however, there no cure for the disease. Red ginseng well known to have anti-AD potential, while red marc (RGM) remaining after extraction regarded as useless discarded. However, it has recently been reported that RGM, particularly fermented RGM (fRGM), still contains bioactive properties. Thus, anti-allergic effects of fRGM were examined in 2,4-dinitrochlorobenzene-induced AD-like mice model. The model was topically treated with distilled water (control), dexamethasone, or six weeks. Treatments alleviated lesions reduced serum IgE levels, compared control. also levels lipid peroxidation superoxide anion; increased glutathione contents, downregulated gene expression inflammatory mediators. Histopathological analyses demonstrated suppressed epidermal thickening, collagen deposition, cell mast infiltration, which involved anti-inflammatory, antioxidant, anti-apoptotic effects. Further, hypertrophic changes responses spleen lymph nodes. beneficial observed dexamethasone groups; antioxidant evident only treatments. These results provide useful information developing therapeutic source AD.